Medical Disclaimer: This content is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before making any health-related decisions. If you are experiencing a medical emergency, call your local emergency services immediately.
What This Page Explains
There is no established recommended dosage for fisetin. Unlike pharmaceutical drugs that undergo Phase III dose-finding trials, fisetin dosing in research has been exploratory and varies significantly between studies. This page summarizes the doses that have been used in published and registered human clinical trials.
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Detailed Evidence
The most commonly studied dosing protocol uses approximately 20 mg/kg/day. For a 70 kg (154 lb) adult, this equates to approximately 1400 mg per day, typically administered for 2 consecutive days, followed by 28 days off — a pattern known as 'hit-and-run' or intermittent senolytic dosing.
Evidence Hierarchy
Systematic Reviews & Meta-Analyses
Multiple high-quality trials combined
Randomized Controlled Trials (RCTs)
Gold standard for treatment efficacy
Observational Studies
Can show associations, not causation
Case Reports & Expert Opinion
Hypothesis-generating only
Preclinical (Lab/Animal) Studies
Should NOT be extrapolated to humans
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Study Quality Indicators
Higher Quality Indicators
- Large sample size (hundreds to thousands)
- Randomized and blinded design
- Placebo-controlled comparison
- Published in peer-reviewed journals
- Replicated in multiple studies
- Registered trial protocol before starting
Lower Quality Indicators
- Small sample size (under 100)
- No control group or blinding
- Manufacturer-funded with conflicts
- Only animal/cell studies
- Never replicated
- Published in predatory journals
Important Limitations
- • Supplement research often has methodological limitations
- • Results from one study may not generalize to all people
- • Marketing claims often exceed what research supports
- • Absence of evidence is not evidence of absence
- • Individual response to supplements varies widely
Quick Answers
What dose of fisetin should I take?
There is no established recommended dosage. Clinical trials have used approximately 20 mg/kg/day (roughly 1400 mg for a 70 kg adult) for 2 consecutive days in intermittent protocols. Consult a qualified healthcare provider.
How often should you take fisetin?
Clinical trials have used intermittent 'hit-and-run' protocols: 2 consecutive days of dosing, followed by 28 days off. This is based on the hypothesis that brief high-dose exposure is sufficient to trigger apoptosis in senescent cells.
What is intermittent senolytic dosing?
Intermittent senolytic dosing involves brief, high-dose exposure (e.g., 2 consecutive days) followed by a recovery period (e.g., 28 days off). The theory is that this is sufficient to clear senescent cells, followed by debris clearance and new cell generation.
Is 100 mg of fisetin enough?
OTC supplements typically contain 100–500 mg per capsule — substantially lower than clinical trial doses of 1400+ mg. It is unclear whether daily low-dose supplementation achieves the same biological effects as intermittent high-dose protocols.
Can I take fisetin every day?
Daily continuous dosing and intermittent senolytic dosing represent fundamentally different biological rationales that have never been compared head-to-head in clinical trials.
How much fisetin per kg body weight?
Clinical senolytic trials use fisetin at approximately 20 mg/kg/day. This means individual doses range from ~1000 mg (50 kg adult) to ~2000 mg (100 kg adult) within the same protocol.
Should fisetin be taken with food?
Mild GI discomfort may occur at higher doses and typically resolves with food. However, specific food-effect studies on fisetin absorption have not been published.
Can I combine fisetin with quercetin?
Research suggests fisetin and quercetin may be synergistic — fisetin handles senescent cell clearance while quercetin builds antioxidant defenses. However, combination protocols have not been rigorously studied in human trials.
Is there a maximum dose of fisetin?
No regulatory body has established a maximum dose or upper intake level (UL) for fisetin. Acute toxicity studies indicate a wide safety margin, but long-term high-dose safety has not been characterized.
What dose did the mouse study use?
The 2018 mouse study used 100 mg/kg/day for 5 consecutive days, which allometrically scales to approximately 500–800 mg/day in humans.
Key Research Facts
Clinical senolytic trials use fisetin at approximately 20 mg/kg/day — roughly 1400 mg for a 70 kg adult — administered for 2 consecutive days.
Strong EvidenceVerdoorn et al., JAGS / Kirkland & Tchkonia — doi:10.1111/jgs.17416
The intermittent 'hit-and-run' dosing protocol is based on the hypothesis that brief high-dose exposure is sufficient to trigger apoptosis in senescent cells.
Moderate EvidenceKirkland & Tchkonia, J Internal Medicine — doi:10.1111/joim.13141
OTC fisetin supplements typically contain 100–500 mg per capsule — substantially lower than clinical trial doses of 1400+ mg.
Strong EvidenceMarket survey — Supplement market analysis
No regulatory body has established a recommended dietary allowance (RDA) or upper intake level (UL) for fisetin.
Strong EvidenceFDA/EFSA regulatory status — Regulatory review
The 2018 mouse study used 100 mg/kg/day for 5 consecutive days, which allometrically scales to approximately 500–800 mg/day in humans.
Moderate EvidenceYousefzadeh et al., EBioMedicine — doi:10.1016/j.ebiom.2018.09.015
The vascular function trial (NCT06133634) uses 20 mg/kg/day for 2 days per month over 3 months — the most rigorous dose-schedule design for fisetin.
Emerging EvidenceClinicalTrials.gov — NCT06133634
Given fisetin's <10% oral bioavailability, the effective systemic dose from a 1400 mg oral dose may be less than 140 mg reaching circulation.
Moderate EvidenceGrynkiewicz & Demchuk, Frontiers in Chemistry — doi:10.3389/fchem.2019.00159
Citations & External Resources
ClinicalTrials.gov — Search: Fisetin
EBioMedicine — Yousefzadeh et al. 2018 (Landmark Senolytic Study)
JAGS — Verdoorn et al. 2021 (Dosing Protocol)
Journal of Internal Medicine — Kirkland & Tchkonia 2020 (Senolytic Review)
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Related Reading
Fisetin: Overview, Evidence & Safety
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References (3)
Written by
ReCellence™ Editorial Team
Health Content Specialists
Medically reviewed by
Medical Review Board
MD, PhD
Last updated: March 8, 2026
Last medical review: March 8, 2026